Every major city and most communities throughout the state have worldwide connectivity through the multi-modal transportation/distribution infrastructure with easily accessible interstate and four-lane highways, motor freight terminals, rail systems, port and barge transportation, and international air service.

Interstates include:
Passenger rail service is provided by Amtrak with three Alabama stops along the Crescent route running daily between New York City and New Orleans. Freight service needs are accommodated through an extensive rail system served by 25 freight railroad companies over 3,700 miles (5,954 km) of track.
Five Class I railway companies providing service to the state include:
Several airports provide air cargo service. These airports have designated foreign trade zones for the promotion of international commerce through the duty-free, quota-free entry of foreign goods under U.S. Customs supervision.
Alabama’s air transportation network features 92 general aviation airports. Most of the public-use airports are able to accommodate corporate jets. Alabama is located between two of the nation's largest air cargo centers – Memphis, Tenn., and Atlanta.
The Alabama State Port Authority operates Alabama’s full-service, deepwater port on the Gulf of Mexico. The Port of Mobile offers terminal services from 100 overseas shipping lines and a dozen towing companies. The port’s container, general cargo and bulk facilities have immediate access to two interstate systems, five Class 1 railroads and nearly 15,000 miles of inland and intracostal waterway connections.
Brookley Airport Complex, adjacent to the port, offers immediate access to freight-forwarding transportation services. The Port of Mobile provides complete service for shippers, including intermodal transfer and handling, warehousing and security.
At 45 feet (13.7 meters), the port’s main channel is one of the deepest permanently navigable channels in the South. With a long history as a bulk handling port and roll-on roll-off, the Port of Mobile has transitioned to a distribution center for general cargos, including forest products, iron and steel, aluminum, copper, frozen poultry, soybeans and chemicals. In 2008, its public facilities handled 28 million tons of cargo.
Port of Mobile specifics includes:
General cargo/intermodal
A $97 million intermodal railroad hub, under construction and set to open in 2012, will annually process 165,000 containers and trailers via six daily trains. The 316-acre site is strategically located next to the confluence of Interstate 459 and Interstate 59 (New Orleans-Chattanooga, Tenn.) and Interstate 20 (South Carolina-Texas.)
Norfolk Southern’s Birmingham Regional Intermodal Facility will be a key component of an ambitious $2.5 billion rework of 2,500 miles of Norfolk Southern tracks linking New Orleans with New York City, serving 30 percent of the nation’s manufacturing output. Some 28 intermodal trains will operate on the Crescent Corridor once fully functional.
The terminal will also provide a strategic link between California and seaports in the Southeast (Mobile, New Orleans, Savannah, Jacksonville).
The facility is less than 5 miles from the Jefferson Metropolitan Park at McCalla. The 739-acre park includes Mercedes-Benz supplier Gestamp, Korean steelmaker Posco, and regional warehouses for Home Depot (600,000 square feet) and OfficeMax (180,000 square feet).